منابع مشابه
Aging-Associated Changes in Hematopoiesis and Leukemogenesis: What's the Connection?
Aging is associated with a marked increase in a number of diseases, including many types of cancer. Due to the complex and multi-factorial nature of both aging and cancer, accurate deciphering of causative links between aging and cancer remains a major challenge. It is generally accepted that initiation and progression of cancers are driven by a process of clonal evolution. In principle, this s...
متن کاملAging of the Microenvironment Influences Clonality in Hematopoiesis
The mechanisms of the age-associated exponential increase in the incidence of leukemia are not known in detail. Leukemia as well as aging are initiated and regulated in multi-factorial fashion by cell-intrinsic and extrinsic factors. The role of aging of the microenvironment for leukemia initiation/progression has not been investigated in great detail so far. Clonality in hematopoiesis is tight...
متن کاملCD137 ligand reverse signaling skews hematopoiesis towards myelopoiesis during aging
CD137 is a costimulatory molecule expressed on activated T cells. Its ligand, CD137L, is expressed on the surface of hematopoietic progenitor cells, and upon binding to CD137 induces reverse signaling into hematopoietic progenitor cells promoting their activation, proliferation and myeloid differentiation. Since aging is associated with an increasing number of myeloid cells we investigated the ...
متن کاملLow-Cell-Number Epigenome Profiling Aids the Study of Lens Aging and Hematopoiesis
Understanding how chromatin modification regulates development and disease can be limited by available material. Despite recent progress, balancing high-quality and reliable mapping using chromatin-immunoprecipitation-based deep sequencing (ChIP-seq) remains a challenge. We report two techniques, recovery via protection (RP)-ChIP-seq and favored amplification RP-ChIP-seq (FARP-ChIP-seq), that p...
متن کاملPolymorphisms of the murine mitochondrial ND4, CYTB and COX3 genes impact hematopoiesis during aging
During aging, mitochondrial DNA (mtDNA) can accumulate mutations leading to increasing levels of reactive oxygen species (ROS). Increased ROS were described to activate formerly quiescent hematopoietic stem cells (HSC). Mutations in mtDNA were shown to enhance the risk for myelodysplastic syndrome and leukemia. However, the complex relationship between mtDNA variations, ROS and aging of the hem...
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ژورنال
عنوان ژورنال: Clinics in Geriatric Medicine
سال: 2019
ISSN: 0749-0690
DOI: 10.1016/j.cger.2019.03.001